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Lignan Research, L.L.C.

Balancing Body, Science and Nature for a Long and Healthy Life

Founded in 1997, Lignan Research specializes in the research, development and manufacture of cutting-edge lignan-based nutraceuticals for proactive health care. Studies show that lignans, a class of phytoestrogens, have a positive, balancing effect on hormone levels in men and women. Lignan Research is particularly focused on advancing the beneficial properties found specifically in SDG (secoisolariciresinol diglycoside) lignan, linked to risk reduction of estrogen-related cancers. Through its pioneering technology, the company has created the first solution to meet the significant challenge of achieving optimal levels of lignan on a daily basis.

Breakthrough Health Strategy

Lignan Research is the world’s first company to isolate, concentrate, purify and standardize lignans at commercial scale. After a long-term research effort and extensive human oral dosing studies, the company will debut Brevail®, the only supplement designed specifically for proactive breast health. Distinguished as one of the most thoroughly researched and tested new nutracueticals in industry history, Brevail provides women a new strategy in maintaining exceptional health and will be available nationwide in Summer 2003. To learn more about Brevail, visit: www.brevail.com.

Cycle of Wellness

To further its mission of promoting women’s health, Lignan Research is forming the Breast Cancer Prevention Foundation, dedicated to prevention-oriented research and education. The non-profit was founded in the memory of Deborah Demos-Palys, the late wife of the company President Raymond Palys. Deborah died at the age of 34 from breast cancer. A percentage of profits from the sale of Brevail will be donated to help fund the Foundation’s research initiatives.

To advance the company’s proactive approach to breast health, Lignan Research is creating an advisory board of biomedical, allopathic and natural health experts, including Dr. Kenneth D. Setchell, the board chairman and Lignan Research’s chief scientific advisor.

A Leader in Proactive Health

Lignan Research founder and CEO, Jade Beutler, is a licensed health care practitioner with more than a decade of hospital and clinical experience. In 1994, Beutler left a senior management position at Kaiser Permanente Medical Center to form NatureMed Research Inc. (NMR), a consulting company dedicated to the research and development of phyto-pharmaceuticals. NMR began focusing specifically on the SDG lignan, because of its promising cancer prevention properties.

To develop techniques that isolated lignans from natural sustainable sources, Beutler collaborated with Dr. Norman Lewis, one of the world’s leading experts on lignans, and the director of the Institute of Biological Chemistry at Washington State University. Lignan Research was formed in 1997 and subsequently won two consecutive Biotechnology Research Grants from The Washington Technology Center (WTC). Beutler was instrumental in creating the first global alliance of leading lignan experts, focused exclusively on the isolation of lignans from flaxseed at commercial scale.

Beutler leads the company’s research and development initiatives in his quest to provide products and education that help others improve their quality of life. Central to Beutler’s long-term vision is a balanced approach that incorporates new proactive health alternatives and creates a culture shift around proactive prevention versus reactive treatment. Through the advances of Lignan Research, Beutler is raising awareness of the benefits of combining natural solutions with science for overall vitality.

Promoting Prevention from the Heart

Raymond Palys was named president of Lignan Research in April 2001, and brings extensive strategic planning and management expertise in the health care, manufacturing and service industries. He plays a critical role in the manufacturing, sales, marketing and distribution of the company’s products. Lignan Research’s mission strikes close to home for Palys, who lost his wife to breast cancer in 1998 and currently supports his sister in her fight against the disease. Palys’ vested interest and strong professional background fuel the company’s efforts to advance disease prevention.

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Brevail® was carefully researched and developed for express use by adult females 18 years or older, and may be used before, during and after menopause. There are no known adverse side effects related to lignan supplementation. As with all nutritional supplements or pharmaceutical drugs, suggested dosages of Brevail should not be exceeded without the advice of a licensed health care professional. Though no negative effects have been reported, Brevail has not been researched in pregnant, lactating, or in women attempting to conceive. Therefore it is advised that use of Brevail be discontinued during these times. Brevail is not intended for use as a breast cancer treatment. Complete scientific validation and research references, are available in the Brevail white paper available online at www.brevail.com.

Brevail® is a registered trademark of Lignan Research, L.L.C.
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